Driving Directions from San Antonio International Airport

Proceed from the main exit from the airport going south and follow the directions to Hwy 281 South. Continue south on Hwy 281 toward downtown San Antonio. (At some point 281 is also known as 37). Take the Commerce Street Exit (141A)  toward downtown, keeping right and exit the ramp towards downtown and merge onto East Commerce Street.  You should be heading west on East Commerce Street.  Turn left onto St. Mary’s Street so that you are heading south.  Cross over the river and the Tower Life Building will be on your left.  Proceed past the building to Villita Street which should be the first left turn. The building's parking garage entrance/exit is located on Villita Street.  As a note, visitor parking at the Tower Life Building is valet parking only.  If you prefer to self-park, you may park on the street or in any nearby public parking lot.